M-125 through the City of Monroe was designated as a Historic Heritage Route. The City of Monroe in conjunction with MDOT nominated the portion of M-125 which runs through the Old Village Historic District, and is contiguous to the East Elm - North Macomb Historic District, and the Custer Equestrian Monument.

M-25 through Bay City was designated as a Historic Heritage Route. The City of Bay City in conjunction with MDOT nominated the 1.5 miles long portion of M-25 which runs from Madison Avenue to Livingston Avenue. Visible from the road is the Bay County Building, which is on the National Register for Historic Places. The area also contains 48 pre-1900 and 32 1900-1929 structures, which are also on the National Register as part of the Center Avenue Historic District.

US-2's Iron County Heritage Trail is 16 miles long and the perfect place to learn the story of iron mining in Michigan. It is an amazing story, started some 1.2 billion years ago, that involves rift minerals, prehistoric mining tools, copper and bronze age, the industrial revolution and world conflicts.

Marshall Territorial Road ( I-94BL) is the location of the country's largest National Historic District in the small urban category. This 14 block area has no fewer than 14 official Michigan Markers. These locations reflect Marshall's early importance in Michigan history, especially in areas of government, education, abolition, railroads, unionism and architecture.

US-12 (Michigan Avenue) through Saline follows the route of the historic Sauk Trail, a Native American trail that was to later become the Detroit and Chicago Road. Orange Risdon the founder of Saline was the original surveyor for the Detroit and Chicago Road. The portion of Michigan Avenue in Saline designated as a Heritage Route has several historic attractions. The old Schuyler Mill (now Weller's) is located near the intersection of US-12 and the Saline River. Henry Ford converted this Mill in 1937 to a soybean processing plant for the manufacture of auto paint and auto parts. The Saline Downtown area is a historically significant and vibrant downtown area. Oakwood Cemetery, Curtiss Mansion and the Rentschler Farm museum are other important attractions.   Click here to see pictures of the heritage route; farm , scenic, town.

US-12 in Clinton and Clinton Township are part of the historic Saulk Trail. Typically, Clinton was founded on the convergence of a road, the Chicago Military Road and a river, The Raisin. The original community was called Oak Opening because of its location in a natural opening in the dense oak forest. Clinton soon became the greatest trading point west of Detroit with ten general stores several blacksmith shops a hardware store, the Clinton Inn, Atlas Mill, and the Clinton Woolen Manufacturing Co. with 200 employees. Today many of the buildings in the Village of Clinton and Clinton Township are faithfully preserved, but with modern conveniences to better serve today's customer.