Key Dates:  Applications Due: April 21, 2009 

Funding decisions and awards will be issued on or prior to September 30, 2009 for applications submitted in response to this notice, and on or prior to September 30, 2010 for applications submitted in response to any reissuance of this notice.  Resubmissions will only be accepted if the notice is reissued.

Program Information: The National Institutes of Health (NIH) will administer grants for investigators and U.S. institutions/organizations with active NIH-supported research project grants to submit revision applications (formerly termed competitive supplements) to support a significant expansion of the scope or research protocol of approved and funded projects.  In addition, Recovery Act funds allocated to NIH specifically for comparative effectiveness research (CER) may be available to support supplements.

Grant Information: Projects receiving these funds will need to meet this definition of CER: "a rigorous evaluation of the impact of different options that are available for treating a given medical condition for a particular set of patients. Such a study may compare similar treatments, such as competing drugs, or it may analyze very different approaches, such as surgery and drug therapy." Such research may include the development and use of clinical registries, clinical data networks, and other forms of electronic health data that can be used to generate or obtain outcomes data as they apply to CER.

For More Information:  View the full Funding Opportunity Announcement for program and application information.