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What is MIS-C?
Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C. However, many children with MIS-C were infected with the virus that causes COVID-19, or had been around someone with COVID-19.
Health care providers and local health departments are asked to maintain a high degree of suspicion for MIS-C in pediatric and adolescent patients presenting with symptoms similar to Kawasaki Disease or ill individuals who have been previously exposed to COVID-19 with signs and symptoms. Patients have presented with persistent fever*, hypotension, multiorgan (cardiac, gastrointestinal, renal, hematologic, dermatologic, and neurologic) involvement, and elevated inflammatory markers. Respiratory symptoms have been present in some, but are not a common finding.
*Persistent fever is a measured fever of 100.4°F (38.0°C) or greater for at least 24 hours, or report of subjective fever lasting at least 24 hours.
Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C)
Data will be updated on the first and third Thursdays of the month.
| # Cases Confirmed and Reported to CDC* | 309 |
|---|---|
| MIS-C associated Deaths | 5 or fewer |
| Cases admitted to ICU | 195 (63.1%) |
| Onset Date Range | 4/14/20 to 7/19/2022 |
| Age Range | 0-20 years |
*Meets CDC Case definition
https://emergency.cdc.gov/han/2020/han00432.asp
| Age Group | Count | % | Race | Count | % |
| <1 yrs | 12 | 3.9% | Black/African American | 107 | 34.6% |
| 1-4 yrs | 76 | 24.6% | Caucasian | 149 | 48.2% |
| 5-11 yrs | 147 | 47.6% | All Others / Unknown | 53 | 17.2% |
| 12-15 yrs | 55 | 17.8% | |||
| 16-20 yrs | 19 | 6.1% | |||
| Gender | Counts | % | Ethnicity | Count | % |
| Male | 194 | 62.8% | Not Hispanic or Latino | 230 | 74.4% |
| Female | 115 | 37.2% | Hispanic or Latino | 28 | 9.1% |
| Unknown | 0 | 0.0% | Unknown | 51 | 16.5% |
Red shading indicates the expected reporting lag for new cases. Cases with onset dates in this time period may not have been detected or reported yet.
