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In the event of an opioid overdose, there is a drug that can be used that can reverse the effects of the opioid. Naloxone (commonly known by the brand names Narcan and Evzio) is a life-saving medication used to reverse the effect of an opioid overdose. Naloxone is not addictive. Payment for the medication Naloxone is covered by Medicaid and many other insurances. Many non-profit organizations also distribute Naloxone.