September 17, 2026: CTX Awareness Day

WHEREAS a diagnosis of a genetic variant on the CYP27A1 gene means an individual could have neurodevelopmental differences, suffer from chronic diarrhea, bilateral cataracts, seizures, tendon xanthomas, difficulty with coordination and balance, and can experience progressive neurological problems over time; and,

WHEREAS CYP27A1 is a gene the provides instructions for producing an enzyme that helps to break down cholesterol to form acids used to digest fats. When there is a variant on this gene, the enzyme does not work properly and prevents these fats from breaking down properly, affecting the eyes, tendons, brain, and other tissues over time; and,

WHEREAS individuals with a variant on the CYP27A1 gene can experience life-altering neurological changes including difficulty with coordination and balance, seizures, and cognitive impairment; and,

WHEREAS treatment options for individuals with a CYP27A1 gene variant are limited to lifetime use of chenodeoxycholic acid replacement therapy which may partially reverse the disease process but cannot reverse damages that have been caused by it; and,

WHEREAS it is imperative that there be greater public awareness of this health issue and more must be done to increase activity at the local, state, and national levels;

NOW, THEREFORE, as Governor of the State of Michigan I do hereby proclaim September 17, 2025, CTX Awareness Day in the Michigan.