The MPART Coordination Structure includes topical workgroups that manage PFAS initiatives, analysis, and research across state agencies. Each topical workgroup is led by a member of the broader Technical Advisory Workgroup, which helps to ensure coordination across the topical workgroups.

As of May 7, 2020, 16 of these multi-agency topical workgroups have been established. Webpages for each workgroup have been created to share their mission, accomplishments, and activities going forward.