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Bovine tuberculosis (TB) is a highly infectious disease caused by a bacterium called Mycobacterium bovis. It primarily affects the respiratory system and can infect most mammals. While human and avian TB have limited transmission to animals, bovine TB can spread to various mammals. In Michigan, there is a core area in the northeastern part of the Lower Peninsula where bovine TB is more common among white-tailed deer and other animals. The disease spreads when infected and uninfected animals come into close contact, through respiratory secretions and sometimes contaminated feed. Bovine TB develops slowly over years, starting in the lymph nodes and progressing to lung and chest cavity lesions. It is a significant challenge for managing livestock and wildlife. Preventive measures and understanding the disease's transmission and development are important for control and protection.