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PEP (Post-Exposure Prophylaxis)
PEP (Post-Exposure Prophylaxis) is a preventive treatment that can reduce the chance that a person who is exposed to HIV will become HIV-positive.
PEP treatment involves two to three different antiretroviral medicines that work together to prevent HIV from making copies of itself and spreading through the body. To be effective, the medicines must be started as soon as possible - but not more than 72 hours (3 days) after - possible exposure to the virus. They also must be taken on schedule for 28 days.
PEP medicines can reduce the risk of becoming HIV-positive. But, they are not always effective. Taking PEP does not guarantee that a HIV infection will be prevented.
For more information about PEP, visit: PEP - CDC.
- MDHHS Guidance for Administration of HIV nPEP (Non-Occupational Post-Exposure Prophylaxis) (rev. December 2021)
- MDHHS nPEP Guidance Excerpts (rev. December 2021)
- Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV - United States, 2016
(Centers for Disease Control and Prevention, 2016)
- Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis
(National Center for Emerging and Zoonotic Infectious Diseases, 2013)