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Post-Exposure Prophylaxis (PEP)
Post-exposure prophylaxis (PEP) is a preventive treatment that can reduce the chance that a person who is exposed to HIV will get HIV.
PEP treatment involves two to three different antiretroviral medicines that work together to prevent HIV from making copies of itself and spreading through the body. To be effective, the medicines must be started as soon as possible—but not more than 72 hours (3 days) after—possible exposure to the virus. They must be taken on schedule for 28 days.
PEP medicines can reduce the chance of getting HIV, but they are not always effective. Taking PEP does not guarantee that a HIV infection will be prevented.
For more information about PEP, visit PEP (CDC).
Find a PEP Provider
PEP providers are medical professionals that can prescribe post exposure prophylaxis (PEP), order necessary laboratory testing and conduct medication adherence counseling. To locate a PEP provider, view Michigan's PrEP and PEP Directory.
Provider Resources
- MDHHS Guidance for Administration of HIV nPEP (Non-Occupational Post-Exposure Prophylaxis) (rev. December 2021)
- MDHHS nPEP Guidance Excerpts (rev. December 2021)
- Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV - United States, 2025 (Centers for Disease Control and Prevention, 2025)
- Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis (National Center for Emerging and Zoonotic Infectious Diseases, 2013)
- PrEP, PEP and Other HIV Prevention Strategies: Billing and Coding Guide (NASTAD, 2023)
The PrEP, PEP and Other HIV Prevention Strategies Billing and Coding Guide includes information and best practices for coding, billing and denial resolution for PrEP and PEP services.