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Mpox Resources for Health Care Professionals

Handout for those exposed – give to confirmed mpox cases to share with close contacts

MDHHS Communicable Disease Information and Resources

Integrating Mpox Vaccination, Testing and Treatment Into Sexual Health and HIV Clinical Care

Information for Veterinarians

For more information or for questions, please contact your local health department. If you need additional information, contact MDHHS Communicable Disease at 517-335-8165.

Clinical Guidance

Mpox Treatment Information

June 2022 CDC Webinar Slides on What Clinicians Need to Know 

CDC Updates about Clinical Diagnosis and Treatment

Considerations for Mpox Vaccination

JYNNEOS Intradermal Injection Final 

JYNNEOS Operational Guide Updated 11-2-2022

JYNNEOS Vaccine Resource Guide

TPOXX Request Procedure


Tecovirimat (TPOXX) may be considered for treatment in people infected with mpox virus.

Prior to ordering, review the TPOXX Request Procedure for eligibility criteria.

  • To request TPOXX for a patient, contact the local health department (LHD). When product is available, requester and the LHD will arrange delivery of product locally.
  • If the local health department is unable to provide TPOXX, then it should be requested from MDHHS through the TPOXX Request Form. This form will solicit needed doses and provide required deidentified patient and provider information. Receipt of the form will be monitored, and approved orders will be supplied within 24 hours after receipt Monday - Friday.

Clinicians can contact the CDC Mpox Clinical Team to request clinical consults regarding treatment, management, etc.

  • Non-urgent inquires: Submit the request by emailing
  • Urgent inquiries: Call the CDC Emergency Operations Center at 770-488-7100.

View TPOXX Request Procedure for additional information.

Mpox Program Provider Guidance

MDHHS Mpox Program Provider Addendum Updated 12-19-2022

HHS/ CDC Mpox Program Provider Agreement 

Mpox Vaccine and Therapeutics Provider Considerations for Approval Updated 10-25-2022


JYNNEOS Vaccine Update - August 26, 2022


MDHHS BOL Testing Basics

Test Requisitions

Increased Commercial Laboratory Capacity for Mpox

MDHHS Bureau of Laboratories (BOL) has the capability to test for orthopoxvirus as the first step in identifying mpox infection. As the need for testing increases, MDHHS is asking that health care providers consider utilizing recently onboarded commercial laboratories to expand testing capacity. This will increase accessibility for patients and health care providers and prevent delays in turnaround times. On June 22, 2022, the Department of Health and Human Services (HHS) announced that Mpox testing capacity would be expanded to five commercial laboratory companies. Currently, the laboratories that can perform orthopoxvirus testing include Aegis Science, Labcorp, Mayo Clinic Laboratories, Quest Diagnostics, and Sonic Healthcare. Onboarding of new laboratories is an evolving environment—check here for any new labs added: What’s New & Updated | Mpox | CDC.

MDHHS has ensured that positive results from MDHHS BOL and the commercial laboratories will be reported into the Michigan Disease Surveillance System (MDSS) via electronic laboratory reporting (ELR). Mpox cases in the MDSS are currently being classified as an “Unusual Outbreak or Occurrence” until a mpox disease-specific form is finalized.

CDC Preparation and Collection of Specimens
Preparation and Collection of Specimens | Mpox | CDC


  • Instructions for specimen collection are found in Investigation of Suspect Cases of Mpox.
  • Please collect a maximum of six swabs (two swabs from each of three sites), preferably lesions that are vesicles, pustules, or scabs. A single site or two sites is preferred.
  • Providers may want to continue to consider testing at MDHHS BOL for individuals who are uninsured/underinsured where commercial testing cost may be a burden. 

Vaccine Administrations

Statewide, local health departments and clinical partners have reported 14,346 total administrations of JYNNEOS vaccine to the Michigan Care Improvement Registry (MCIR) through Monday, March 13, 2023.

*Doses administered are reported by providers and can be subject to delays. Previously reported numbers may change as new reports are received. MDHHS pulls the data for cleaning and posts to the website bi-weekly every other Tuesday.


May 20, 2022 HAN

June 14, 2022 HAN