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Histoplasmosis is a fungal disease. The organism Histoplasma causes histoplasmosis.1 The fungal disease happens when a person breathes in fungal spores from infected soil or other decomposing matter that is disturbed (digging in dirt, raking leaves, etc.). Infected soil often contains bird or bat droppings. Histoplasma is found in some central and eastern states including Michigan.2
Most people who breathe in Histoplasma spores do not get sick. Those people who do get sick may develop fever, cough and fatigue. Most people get better on their own without treatment. Infection can be severe in some people, such as those with weakened immune systems.3
Between 2016-2020, an average of 186 human cases of histoplasmosis were reported each year to the Michigan Department of Health and Human Services (MDHHS).4
Histoplasmosis data are available on the MiTracking Data Portal.
Histoplasma is a dimorphic fungus, which means it exists in two different forms, mold and yeast, based on temperature. It grows as a mold at outside air temperatures. The mold develops spores called conidia. Disturbing contaminated soil can lead to breathing in fungal spores. The spores then transform into a yeast at higher temperatures found inside the human body. The yeast can stay in the lungs or spread through the bloodstream to other parts of the body.2
For more information, visit CDC – About Histoplasmosis.
Anyone can get histoplasmosis if they have been in an area where Histoplasma lives.2
Some people are at higher risk for severe illness, including:
Histoplasmosis does not spread from person to person. Organ transplants have passed the infection in rare cases.4
For more information, visit CDC – Reducing Risk for Histoplasmosis.
Most people never have symptoms. Other people may have symptoms that go away on their own. Symptoms occur within three to 17 days after breathing in the fungal spores.
Histoplasmosis symptoms include:
Severe disease is more common in people with weakened immune systems. The infection can spread from the lungs to other parts of the body.3
For more information, visit CDC - Symptoms of Histoplasmosis.
Some people (see “Risk Factors”) are at higher risk for severe disease.
People with weakened immune systems should avoid:
Professional companies specializing in hazardous waste removal should clean up large amounts of bird or bat droppings.
For more information, visit CDC – Reducing Risk for Histoplasmosis and Occupational Histoplasmosis – Prevention Measures.
Healthcare providers will first gather information about a patient’s1:
They will then conduct a physical examination.
Healthcare providers can test for histoplasmosis by collecting a blood or urine sample. A patient’s healthcare provider will order more tests as needed.
In pneumonia patients who are not getting better on antibiotics, physicians need to rule out histoplasmosis or other fungal infections.
For severe, chronic or disseminated cases, antifungal medication is recommended.5
For more information, visit CDC – Fungal Diseases.
Histoplasmosis is reportable in certain states, including Michigan. Physicians and laboratories are required to report suspected cases of histoplasmosis to the Michigan Disease Surveillance System or the local health department.
For additional data information, visit:
Multistate Epidemiology of Histoplasmosis, United States, 2011–2014 (Healthcare providers)
Travel-Associated Infections and Diseases: Histoplasmosis
What Employers Need to Know about Histoplasmosis (Fact Sheet)
1. CDC. Histoplasmosis. About Histoplasmosis. https://www.cdc.gov/histoplasmosis/about/index.html. Accessed August 21, 2024
2. CDC. Histoplasmosis. How People Get Histoplasmosis. https://www.cdc.gov/histoplasmosis/causes/?CDC_AAref_Val=https://www.cdc.gov/fungal/diseases/histoplasmosis/causes.html. Accessed August 21, 2024.
3. CDC. Histoplasmosis. Symptoms of Histoplasmosis. https://www.cdc.gov/histoplasmosis/signs-symptoms/?CDC_AAref_Val=https://www.cdc.gov/fungal/diseases/histoplasmosis/symptoms.html. Accessed August 21, 2024.
4. CDC. Histoplasmosis. Reducing Risk for Histoplasmosis. https://www.cdc.gov/histoplasmosis/prevention/?CDC_AAref_Val=https://www.cdc.gov/fungal/diseases/histoplasmosis/risk-prevention.html. Accessed August 21, 2024.
5. American Lung Association. Treating and Preventing Histoplasmosis. https://www.lung.org/lung-health-diseases/lung-disease-lookup/histoplasmosis/treatment. Accessed August 21, 2024.
