What is MIS-C?
Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C. However, many children with MIS-C were infected with the virus that causes COVID-19, or had been around someone with COVID-19.
Health care providers and local health departments are asked to maintain a high degree of suspicion for MIS-C in pediatric and adolescent patients presenting with symptoms similar to Kawasaki Disease or ill individuals who have been previously exposed to COVID-19 with signs and symptoms. Patients have presented with persistent fever*, hypotension, multiorgan (cardiac, gastrointestinal, renal, hematologic, dermatologic, and neurologic) involvement, and elevated inflammatory markers. Respiratory symptoms have been present in some, but are not a common finding.
*Persistent fever is a measured fever of 100.4°F (38.0°C) or greater for at least 24 hours, or report of subjective fever lasting at least 24 hours.
Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C)
Data will be updated on the first and third Thursdays of the month.
|# Cases Confirmed and Reported to CDC*||227|
|MIS-C associated Deaths||5 or fewer|
|Cases admitted to ICU||154 (67.8%)|
|Onset Date Range||4/14/20 to 1/1/2022|
|Age Range||0-20 years|
*Meets CDC Case definition
|0-4 yrs||59||26.0%||Black/African American||85||37.5%|
|>10 yrs||79||34.8%||All Others / Unknown||38||16.7%|
|Male||141||62.1%||Not Hispanic or Latino||165||72.7%|
|Female||86||37.9%||Hispanic or Latino||21||9.2%|
Red shading indicates the expected reporting lag for new cases. Cases with onset dates in this time period may not have been detected or reported yet.
- MIS-C Fast Fact Sheet
- Additional information on laboratory testing, other evaluations and treatment are available at CDC's MIS-C webpage: https://www.cdc.gov/mis-c/hcp/.
- CDC Case definition - https://emergency.cdc.gov/han/2020/han00432.asp
- A recent study of MIS-C patients in a Detroit-area hospital system is available at https://www.ajemjournal.com/article/S0735-6757(20)30873-1/fulltext.