What is MIS-C?
Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C. However, many children with MIS-C were infected with the virus that causes COVID-19, or had been around someone with COVID-19.
Health care providers and local health departments are asked to maintain a high degree of suspicion for MIS-C in pediatric and adolescent patients presenting with symptoms similar to Kawasaki Disease or ill individuals who have been previously exposed to COVID-19 with signs and symptoms. Patients have presented with persistent fever*, hypotension, multiorgan (cardiac, gastrointestinal, renal, hematologic, dermatologic, and neurologic) involvement, and elevated inflammatory markers. Respiratory symptoms have been present in some, but are not a common finding.
*Persistent fever is a measured fever of 100.4°F (38.0°C) or greater for at least 24 hours, or report of subjective fever lasting at least 24 hours.
Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C)
Data will be updated on the first and third Thursdays of the month.
|# Cases Confirmed and Reported to CDC*||101|
|MIS-C associated Deaths||5 or fewer|
|Cases admitted to ICU||71 (70.3%)|
|Onset Date Range||04/14/20 to 3/13/2021|
|Age Range||0-20 years|
*Meets CDC Case definition
|0-4 yrs||25||24.7%||Black/African American||38||37.6%|
|>10 yrs||33||32.7%||All Others / Unknown||17||16.8%|
|Male||56||55.4%||Not Hispanic or Latino||64||63.4%|
|Female||45||44.6%||Hispanic or Latino||11||10.9%|
Red shading indicates the expected reporting lag for new cases. Cases with onset dates in this time period may not have been detected or reported yet.
- MIS-C Fast Fact Sheet
- Additional information on laboratory testing, other evaluations and treatment are available at CDC's MIS-C webpage: https://www.cdc.gov/mis-c/hcp/.
- CDC Case definition - https://emergency.cdc.gov/han/2020/han00432.asp
- A recent study of MIS-C patients in a Detroit-area hospital system is available at https://www.ajemjournal.com/article/S0735-6757(20)30873-1/fulltext.