MIS-C Reporting
What is MIS-C?
Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C. However, many children with MIS-C were infected with the virus that causes COVID-19, or had been around someone with COVID-19.
Health care providers and local health departments are asked to maintain a high degree of suspicion for MIS-C in pediatric and adolescent patients presenting with symptoms similar to Kawasaki Disease or ill individuals who have been previously exposed to COVID-19 with signs and symptoms. Patients have presented with persistent fever*, hypotension, multiorgan (cardiac, gastrointestinal, renal, hematologic, dermatologic, and neurologic) involvement, and elevated inflammatory markers. Respiratory symptoms have been present in some, but are not a common finding.
*Persistent fever is a measured fever of 100.4°F (38.0°C) or greater for at least 24 hours, or report of subjective fever lasting at least 24 hours.
Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C)
Data will be updated on the first and third Thursdays of the month.
| # Cases Confirmed and Reported to CDC* | 58 |
|---|---|
| MIS-C associated Deaths | 5 or fewer |
| Cases admitted to ICU | 42 (72.4%) |
| Onset Date Range | 04/14/20 to 12/14/20 |
| Age Range | 0-20 years |
*Meets CDC Case definition
https://emergency.cdc.gov/han/2020/han00432.asp
| Age Group | Count | % | Race | Count | % |
|---|---|---|---|---|---|
| 0-4 yrs | 16 | 27.6% | Black/African American | 26 | 44.8% |
| 5-10 yrs | 24 | 41.4% | Caucasian | 26 | 44.8% |
| >10 yrs | 18 | 31.0% | All Others / Unknown | 6 | 10.4% |
| Gender | Counts | % | Ethnicity | Count | % |
| Male | 28 | 48.3% | Not Hispanic or Latino | 33 | 56.9% |
| Female | 30 | 51.7% | Hispanic or Latino | 6 | 10.3% |
| Unknown | 0 | 0.0% | Unknown | 19 | 32.8% |
- MIS-C Fast Fact Sheet
- Additional information on laboratory testing, other evaluations and treatment are available at CDC’s MIS-C webpage: https://www.cdc.gov/mis-c/hcp/.
- CDC Case definition - https://emergency.cdc.gov/han/2020/han00432.asp
- A recent study of MIS-C patients in a Detroit-area hospital system is available at https://www.ajemjournal.com/article/S0735-6757(20)30873-1/fulltext.
