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Doxycycline Post-Exposure Prophylaxis (Doxy PEP)

Doxycycline as STI Post-Exposure Prophylaxis (Doxy PEP)

Doxycycline post-exposure prophylaxis (doxy PEP) has proven to reduce the chance of getting a bacterial sexually transmitted infection (STI) for gay, bisexual, and other men who have sex with men and transgender women that are more likely to get these infections (specifically, syphilis, chlamydia, gonorrhea). The Michigan Department of Health and Human Services (MDHHS) highly encourages the adoption of doxy PEP to combat alarming increases in bacterial STIs in Michigan.

The Centers for Disease Control and Prevention (CDC) recommends health care providers discuss doxy PEP with all gay, bisexual, and other men who have sex with men and transgender women with a history of at least one bacterial STI (syphilis, chlamydia, gonorrhea) in the last 12 months. If offering doxy PEP, health care providers should write a prescription for self-administration of 200 mg of doxycycline within 72 hours of sex. 

MDHHS’s 340B program can be used by covered entities to procure medications for patients to be treated with doxy PEP. Doxy PEP unit dose (UD) 200 mg packets and doxy PEP in #60 bottles (can be used 30 times) are both available through the warehouse via your normal ordering process. 

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